The Broncos visit the 49ers on Sunday, Oct. 4, at 4:25 p.m. ET at Levi's Stadium in Santa Clara. San Francisco is 3-0 and playing without Nick Bosa, its best pass rusher, while Denver is 2-1 and has needed late-game heroics from Bo Nix to win each of its last two. Kalshi traders have the 49ers priced at 59% to win.
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When and where do the Broncos play the 49ers in Week 4 of the 2026 season?
The Broncos and 49ers kick off Sunday, Oct. 4, at 4:25 p.m. ET at Levi's Stadium in Santa Clara, California.
Who is favored to win the Broncos vs. 49ers Week 4 game?
Denver went 14-3 in 2025, won the AFC West, beat Buffalo in overtime in the divisional round and lost the AFC Championship Game to New England, 10-7. Sean Payton handed play-calling duties to new offensive coordinator Davis Webb this offseason. The Broncos are 2-1 after a 31-10 loss at Kansas City in Week 1, in which they gained 176 yards, followed by comeback wins over Jacksonville and the Rams. Bo Nix has four touchdown passes and three interceptions, and Denver has scored 10 first-half points in three games. As of this writing, linebacker Dondrea Tillman (hamstring) is out.
San Francisco went 12-5 in 2025, won at Philadelphia in the Wild Card round and lost 41-6 at Seattle in the divisional round. The 49ers signed wide receiver Mike Evans from Tampa Bay in free agency and are 3-0, with Brock Purdy posting a 133.1 QBR in last week's win over Arizona and throwing one interception this season. As of this writing, Bosa (knee/calf), defensive end Mykel Williams (knee) and defensive tackle James Thompson Jr. (ankle) are out, while Evans (ribs), linebackers Dre Greenlaw (quad) and Jaden Dugger (shoulder) and defensive end Keion White (hamstring) are questionable.
Kalshi power rankings
The 49ers enter as the No. 3 team in the league with a Power Score of 85.2 and a 79% playoff qualification price, while the Broncos rank 10th with a Power Score of 63.0 and a 68% playoff price, a seven-spot gap heading into Santa Clara. See the full 2026 NFL market-implied power rankings.
What the Kalshi market says
Kalshi traders have the 49ers at 59% to win and the Broncos at 41%. San Francisco is favored at home despite the Bosa absence, with Purdy's efficiency and the 49ers' 3-0 record giving them the edge.
What is the point spread for Broncos vs. 49ers in Week 4?
Kalshi traders have the 49ers winning by more than 2.5 points at 54% as of this writing.
What is the projected point total?
Kalshi traders have the over on 47.5 total points at 54% as of this writing.
What is the biggest storyline in the Broncos vs. 49ers Week 4 game?
Bosa's absence removes San Francisco's best pass rusher against a Broncos offense that has needed time to get going in every game this season. Nix has led comeback wins in each of the last two weeks, and Denver's defense scored a touchdown against the Rams in Week 3 when safety Talanoa Hufanga returned an interception 66 yards.
What are the Broncos' and 49ers' expectations for the 2026 season?
Denver Broncos: Denver is trying to follow a 14-3 season with another deep run under a first-year play-caller. Kalshi traders have the Broncos at 68% to make the playoffs and 5% to win the championship.
San Francisco 49ers: The 49ers are trying to get past the divisional round after the 41-6 loss at Seattle last January. Kalshi traders have San Francisco at 79% to make the playoffs, 17% to win the NFC and 10% to win the championship.
Conclusion
Kalshi traders have the 49ers at 59% to win, a slim edge for the home team. Whether Denver's offense can start faster against a San Francisco defense without Bosa is the swing factor. Kalshi's prices for Broncos vs. 49ers will keep moving as kickoff approaches.
What are the score predictions for Broncos vs. 49ers? As of this writing, Kalshi traders have the over on 47.5 total points at 54%.
What is the spread for Broncos vs. 49ers? As of this writing, Kalshi traders have the 49ers winning by more than 2.5 points at 54%.
Who is favored to win, Broncos or 49ers? As of this writing, Kalshi traders have the 49ers at 59% to win.
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