The Cardinals visit the Giants on Sunday, Oct. 4, at 1 p.m. ET at MetLife Stadium. Kalshi traders have the Cardinals at 56% to win, with Jameis Winston starting for the Giants after Jaxson Dart's season-ending knee injury.

For informational purposes only. Not financial advice. See full disclaimer below. Kalshi is not affiliated with the NFL.

Who is favored to win the Cardinals vs. Giants Week 4 game?

The Cardinals are 1-2 after a 31-7 loss to Seattle in Week 2 and a loss at San Francisco in Week 3, with Jacoby Brissett at quarterback and rookie running back Jeremiyah Love coming off a 90-yard game against the 49ers. As of this writing, safety Dadrion Taylor-Demerson (back) is out, Josh Sweat (groin) is questionable, and starting cornerback Will Johnson is on injured reserve with a season-ending neck injury.

The Giants are 2-1 after beating Dallas in Week 1 and Tennessee in Week 3, with a 28-6 loss to the Rams in between, the game in which Dart got hurt and Winston took over. Winston has completed 25 of 49 passes for 229 yards with no touchdowns and one interception since. As of this writing, the Giants have no players listed with an injury designation, though edge rusher Brian Burns is out for the season with a torn ACL.

Kalshi power rankings

The Giants enter as the No. 24 team in the league with a Power Score of 25.0 and a 19% playoff qualification price, while the Cardinals rank 29th with a Power Score of 14.8 and a 6% playoff price, a five-spot gap that runs opposite to the game price. See the full 2026 NFL market-implied power rankings.

What the Kalshi market says

Kalshi traders have the Cardinals at 56% to win and the Giants at 44%. Arizona is a slight favorite on the road despite ranking five spots lower in the Kalshi power rankings.

What is the point spread for Cardinals vs. Giants in Week 4?

Kalshi traders have the Cardinals winning by more than 2.5 points at 49% as of this writing.

What is the projected point total?

Kalshi traders have the over on 44.5 total points at 48% as of this writing.

What is the biggest storyline in the Cardinals vs. Giants Week 4 game?

New York's quarterback room changed again this week. The Giants acquired J.J. McCarthy from Minnesota on Sept. 28 for a 2027 fifth-round pick after Dart's injury, but Harbaugh has said Winston remains the starter and the team is still deciding whether McCarthy will be its second- or third-string quarterback. Winston signed a two-year extension earlier this month, and the Giants have scored 18 points in the two games since he replaced Dart.

What are the Cardinals' and Giants' expectations for the 2026 season?

Arizona Cardinals: The Cardinals are trying to climb out of a 3-14 season under a first-year head coach. Kalshi traders have Arizona at 6% to make the playoffs.

New York Giants: The Giants are in year one under Harbaugh after a 4-13 finish and are trying to stay in the race without their starting quarterback. Kalshi traders have New York at 19% to make the playoffs.

Conclusion

Kalshi traders have the Cardinals at 56% to win, a slight edge for the road team in a matchup of two teams with low playoff prices. Whether Winston can find his footing against an Arizona defense missing Will Johnson is the swing factor. Kalshi's prices for Cardinals vs. Giants will keep moving as kickoff approaches.

What are the score predictions for Cardinals vs. Giants? As of this writing, Kalshi traders have the over on 44.5 total points at 48%.

What is the spread for Cardinals vs. Giants? As of this writing, Kalshi traders have the Cardinals winning by more than 2.5 points at 49%.

Who is favored to win, Cardinals or Giants? As of this writing, Kalshi traders have the Cardinals at 56% to win.

Follow Kalshi on X: @Kalshi | Image source: Erik Drost

The opinions and perspectives presented in this article belong solely to the author. This is not financial advice and does not constitute an offer, solicitation, or recommendation to trade any specific product. Information is provided for convenience only on an "AS IS" basis. Past performance is not necessarily indicative of future results. 18+ only. Restrictions and eligibility requirements apply. Trading event contracts and trading leveraged products, including perpetual futures, involves significant risk and is not appropriate for everyone. Please carefully consider if it is appropriate for you in light of your personal financial circumstances. Kalshi products are not available in all jurisdictions. See kalshi.com/regulatory for more information. Kalshi is subject to U.S. regulatory oversight by the CFTC. Kalshi is not affiliated with the National Football League.