Panthers vs Jaguars odds: Carolina favored as Jacksonville's O-line injuries mount

The Carolina Panthers travel to face the Jacksonville Jaguars on Friday, August 21, with kickoff at 7:30 p.m. ET at EverBank Stadium in Jacksonville. Carolina is priced at 54% and Jacksonville at 47% on Kalshi, as of this writing.

Carolina lost to Buffalo 29-14 in its preseason opener, while Jacksonville opened with a 24-20 win over New Orleans behind a roster of backups and reserves. Both teams enter Week 2 needing a clearer look at their offensive lines, with Jacksonville particularly thin after a wave of camp injuries.

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Matchup: Carolina Panthers vs. Jacksonville Jaguars
Kickoff: Friday, August 21, 7:30 p.m. ET
Venue: EverBank Stadium, Jacksonville, Florida
Watch: Regional only — CBS47 (Jacksonville market), Panthers Television Network (Carolina market)
Kalshi's current number: 54% Carolina Panthers / 47% Jacksonville Jaguars (as of this writing)

Carolina's number has jumped since midweek while Jacksonville's has fallen, a shift that lines up with Jacksonville's mounting offensive line injuries more than any change in Carolina's outlook. Carolina placed outside linebacker Nic Scourton, who tied for the team sack lead in 2025, on injured reserve with a knee injury, ending his season. Wide receiver Ja'seem Reed suffered a calf injury against Buffalo, and outside linebacker Cam Gill is playing through a shoulder issue, per source.

Jacksonville right guard Patrick Mekari underwent a back procedure that will sideline him for an extended stretch, and wide receiver Parker Washington and running back LeQuint Allen Jr. are both dealing with undisclosed injuries heading into this week's joint practices.

Jaguars two-way player Travis Hunter continues splitting reps between wide receiver and cornerback through this week's joint practices with Carolina, with coach Liam Coen still undecided on how many snaps his starters will see Friday.

The two teams have shared a joint-practice field in Jacksonville this week, their first head-to-head look at each other's rosters since last season.

Kalshi traders give Carolina a 49% probability of winning by more than 1.5 points, as of this writing.

Kalshi traders give the game a 47% probability of going over 37.5 combined points, as of this writing.

Kalshi traders have Carolina at 23% to win the NFC South, third among the division's four teams.

Kalshi traders have Jacksonville at 29% to win the AFC South, second among the division's four teams.

Kalshi markets now predict:

When is Panthers vs. Jaguars? Friday, August 21, 2026, with kickoff at 7:30 p.m. ET.
Where is the game? EverBank Stadium in Jacksonville, Florida.
How can I watch? Regionally on CBS47 in Jacksonville and the Panthers Television Network in Carolina.
What is Kalshi's current number? Carolina is a 54% favorite over Jacksonville, as of this writing.

Carolina enters Friday as the favorite, with Jacksonville working through a bank of offensive line injuries.

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