Saints vs. Rams odds: New Orleans favored as both teams sideline starters

The New Orleans Saints host the Los Angeles Rams at SoFi Stadium for Saturday's matchup at 4:00 p.m. ET. The market prices New Orleans at 53% and Los Angeles at 47%, as of this writing.

Both teams are entering their second preseason tune-up under stable leadership, with New Orleans' Kellen Moore continuing to develop Tyler Shough and Los Angeles' Sean McVay sticking to his longstanding approach of resting established starters. Shough is expected to again sit behind backups Saturday, continuing the pattern from preseason Week 1.

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Traders have the Saints as a modest favorite at 53% to the Rams' 47%, as of this writing, despite New Orleans' 0-1 preseason start. The number leans on roster math rather than form, with Los Angeles again expected to withhold most of its established starters regardless of the game's outcome.

According to Kalshi's 2026 NFL market-implied power rankings, Los Angeles enters as the No. 1 team in the league while New Orleans ranks 30th, one of the widest gaps in this week's slate.

New Orleans' injury list is headlined by rookie receiver Jordyn Tyson, who suffered a hamstring injury in joint practices and is expected to miss roughly two months, putting his availability for the start of the regular season in serious doubt.

Los Angeles' report centers on two players banged up in the Week 1 win over Kansas City: rookie offensive lineman Keagen Trost and receiver Mario Williams are both considered week-to-week with hamstring injuries, while receiver Puka Nacua (psoas) and edge rusher Myles Garrett (knee) also remain out of practice, though McVay wasn't planning to play either regardless of health.

Neither marquee quarterback is expected to see the field. Shough is projected to sit for a second straight week, and Matthew Stafford has not played in the preseason since before he arrived in Los Angeles, with McVay's cautious approach unchanged this summer.

That leaves the door open for backups to make an impression again. Rookie quarterback Ty Simpson threw two touchdown passes in Los Angeles' preseason Week 1 win and could see another extended look, while New Orleans continues auditioning its quarterback room behind Shough with Zach Wilson and Spencer Rattler in the mix.

New Orleans is priced at 49% to win by more than 1.5 points, as of this writing.

The total is priced at 50% to go over 37.5 points, as of this writing.

New Orleans is priced at 30% to win the NFC South, as of this writing, with Tampa Bay leading the division at 31%.

Los Angeles leads the NFC West at 49%, as of this writing, ahead of Seattle at 29%.

Kalshi markets now predict:

When is New Orleans vs. Los Angeles? Saturday, August 22, 2026, at 4:00 p.m. ET.
Where is the game? SoFi Stadium in Inglewood, California.
How can I watch? Local broadcast.
What is Kalshi traders' current number? New Orleans is priced at 53% and Los Angeles at 47%, as of this writing.

New Orleans holds a narrow edge, with Kalshi traders pricing the Saints at 53% as both teams again plan to keep their top quarterbacks out of action.

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