USC vs. Fresno State odds: Trojans heavily favored over Bulldogs

No. 14 USC, already 1-0 after a lopsided Week 0 win, hosts Fresno State on Friday night at the Los Angeles Memorial Coliseum in Fresno State's first game as a member of the reconstituted Pac-12. The market has USC priced at 94% and Fresno State at 8%, as of this writing, with kickoff at 9 p.m. ET on FOX.

USC opened its third season of Big Ten membership with a 42-26 win over San Jose State, a game that was more lopsided than the final score indicated. Fresno State is playing its first season as a member of the reconstituted Pac-12 after previously competing in the Mountain West.

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Snapshot

Kalshi traders have priced USC at 94%, with volume on the contract topping $1.6 million. USC is priced at 52% to win by over 21.5 points on the companion spread market, a slightly tighter line than the moneyline number alone might suggest for a 14-point Week 1 favorite of this size.

Specific injury designations for either team are unknown as of this writing. USC's offensive line and skill-position group return largely healthy after Week 0.

USC's headline story is continuity at quarterback rather than change. Jayden Maiava opened his redshirt senior season with a Heisman-caliber performance in Week 0, completing 25 of 29 passes for 286 yards and two touchdowns through the air, plus a rushing score, in a game USC led 28-0 at halftime.

Fresno State's angle is the opposite: a notable return from injury at the position. Head coach Matt Entz named Jayden Mandal the starting quarterback this week. Mandal has attempted only nine career passes dating to 2024 and has worked back from an ulnar nerve transposition surgery, a UCL tear in his throwing arm, a shoulder cyst, and a torn labrum, but has said he is fully healthy heading into his first extended action.

Kalshi traders have USC winning by over 21.5 points priced at 52%, as of this writing.

The market has the over on 51.5 total points priced at 50%, as of this writing.

Kalshi traders have USC priced at 3% on the national championship market, as of this writing.

Kalshi traders have USC priced at 6% on the Big Ten championship market, behind Ohio State, Oregon, and Indiana atop the board, as of this writing.

Kalshi markets now predict:

When is Fresno State vs. USC? The game kicks off Friday, Sept. 4, at 9 p.m. ET.

Where is the game? Los Angeles Memorial Coliseum in Los Angeles, California.

How can I watch? The game airs on FOX.

What is Kalshi traders' current number? USC is priced at 94% and Fresno State at 8%, as of this writing.

USC opens as a heavy home favorite behind a quarterback coming off a Heisman-caliber Week 0, with Kalshi traders pricing the Trojans at 94% over a Fresno State team breaking in a new starter.

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