The Los Angeles Chargers (0-2) visit the Buffalo Bills (2-0) on Sunday, Sept. 27 at 1 p.m. ET at Highmark Stadium. Kalshi traders have the Bills at 76% to win and stay unbeaten.
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When and where do the Chargers play the Bills in Week 3 of the 2026 season?
The Chargers and Bills kick off Sunday, Sept. 27 at 1 p.m. ET at Highmark Stadium in Orchard Park, New York, on FOX.
Who is favored to win the Chargers vs. Bills Week 3 game?
Buffalo went 12-5 in 2025, won a Wild Card game at Jacksonville, and lost in overtime at Denver in the Divisional round. The Bills fired Sean McDermott after that loss and promoted offensive coordinator Joe Brady to head coach, then traded for receiver DJ Moore from Chicago in March. They have opened Brady's first season with a 36-31 win at Houston and a 41-31 win over Detroit. Moore (shoulder) and fellow starting receiver Keon Coleman (ankle) are both questionable and will be game-time decisions after limited practices Friday, while defensive tackle Ed Oliver (hip) is questionable but practiced fully. Defensive back Jordan Hancock and defensive lineman T.J. Sanders are out, as of this writing.
Los Angeles went 11-6 for the second straight season under Jim Harbaugh, then lost 16-3 at New England in the Wild Card round. Harbaugh fired offensive coordinator Greg Roman after that game, and former Dolphins head coach Mike McDaniel now runs the offense. The results have been rough: two 26-14 home losses, to Arizona and Las Vegas, with Justin Herbert completing 59.3% of his passes with two touchdowns and three interceptions. Tight end David Njoku is on injured reserve and Charlie Kolar is out after forearm surgery, and the Chargers have also ruled out left guard Kayode Awosika, guard Trey Pipkins III, defensive tackle Dalvin Tomlinson, safety Elijah Molden, and rookie receiver Brenen Thompson. Safety Derwin James (finger) carries no game designation and is set to play, as of this writing.
Kalshi power rankings
The Bills enter as the No. 1 team in the league with a Power Score of 93.1, and Kalshi traders have them at 92% to qualify for the playoffs. The Chargers rank 26th with a Power Score of 20.7, and Kalshi traders have them at 21% to reach the postseason. That is a 25-spot gap heading into Sunday, after Buffalo climbed two spots this week and Los Angeles fell six.
What the Kalshi market says
Kalshi traders have the Bills at 76% to win and the Chargers at 24%, as of this writing. That makes Buffalo a clear favorite at home against a team still looking for its first win.
What is the point spread for Chargers vs. Bills in Week 3?
Kalshi traders have the Bills winning by more than 7.5 points at 49%, as of this writing.
What is the projected point total?
Kalshi traders have over 49.5 total points at 52%, as of this writing.
What is the biggest storyline in the Chargers vs. Bills Week 3 game?
It is the calendar. Buffalo is the start of a seven-game run for Los Angeles that also includes Seattle, Denver, Kansas City, the Rams, Houston, and Baltimore. The Chargers have scored 14 points in each of their first two games, and they will be without two tight ends and two offensive linemen against a Bills offense that has topped 35 in both of its games. Herbert has been sacked six times already, and a third loss here would put Los Angeles in a deep hole before the toughest part of its schedule even starts.
What are the Chargers' and Bills' expectations entering the 2026 season?
Los Angeles Chargers: Harbaugh has won 11 games in each of his two seasons but has not won a playoff game. The Chargers entered 2026 aiming for a third straight postseason trip and their first AFC West title in 16 years, with a new offensive coordinator in McDaniel.
Buffalo Bills: Buffalo opened its new Highmark Stadium this season under a new head coach, with Allen still at the center of everything. The Bills are trying to win back the AFC East after finishing second in 2025.
Conclusion
Kalshi traders have Buffalo at 76% against a Chargers team that has not found its offense under McDaniel. The swing factor is whether Los Angeles can protect Herbert well enough to keep pace. Kalshi's prices for Chargers vs. Bills will keep moving until the game ends.
What are the score predictions for Chargers vs. Bills? Kalshi traders have over 49.5 total points at 52%, as of this writing.
What is the spread for Chargers vs. Bills? Kalshi traders have the Bills winning by more than 7.5 points at 49%, as of this writing.
Who is favored to win, the Chargers or the Bills? Kalshi traders have the Bills at 76% to win, as of this writing.
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