The Indianapolis Colts and Kansas City Chiefs meet Sunday, September 20 at 8:20 p.m. ET at GEHA Field at Arrowhead Stadium in Kansas City. Both teams enter 1-0. Kalshi traders have the Chiefs at 72% to win and the Colts at 28%.
For informational purposes only. Not financial advice. See full disclaimer below. Kalshi is not affiliated with the NFL.
Who is favored to win the Colts-Chiefs Week 2 game?
Indianapolis finished 8-9 in 2025 under head coach Shane Steichen, with Daniel Jones taking over the starting quarterback job before an Achilles injury ended his season in Week 14. Jones returned from that injury in time for Week 1 and remains the starter alongside Steichen, and the Colts opened 2026 with a lopsided 41-23 loss to Baltimore. Backup quarterback Anthony Richardson, who missed most of 2025 with an orbital eye injury, was held out of Wednesday's practice with a groin injury, though wide receiver Ashton Dulin is one of the only other notable names on the injury report.
Kansas City finished 6-11 in 2025 and missed the playoffs after quarterback Patrick Mahomes tore his ACL and LCL in Week 15, ending his season. Mahomes underwent surgery in December and returned for the Chiefs' 31-10 Week 1 win over Denver behind head coach Andy Reid. Kansas City also added running back Kenneth Walker III in free agency, who ran for 173 yards and two touchdowns in his debut. Left tackle Josh Simmons (back) and safety Chamarri Conner (knee) both remain out of practice.
Kalshi power rankings
The Chiefs enter as the No. 2 team in the league with a Power Score of 93.0 and a 77% playoff qualification price, while the Colts rank 27th with a Power Score of 19.7 and a 30% playoff price, a 25-spot gap heading into Sunday's game.
What the Kalshi market says
Kalshi traders have the Chiefs at 72% and the Colts at 28% as Kansas City opens as a clear favorite at home.
What is the point spread for Colts vs. Chiefs in Week 2?
Kalshi traders predict the Chiefs to be favored by 6 points over the Colts, as of this writing.
What is the projected point total?
Kalshi traders predict a point total of 46 for Sunday's game, as of this writing.
What is the biggest storyline in the Colts-Chiefs Week 2 game?
The sharpest storyline is Patrick Mahomes's return from a torn ACL and LCL that ended his 2025 season and knocked Kansas City out of the playoffs. He looked sharp enough in Week 1, and a home matchup with Indianapolis is a chance to build on that.
What are the Colts' and Chiefs' expectations entering the 2026 season?
Indianapolis Colts: After finishing 8-9 with Daniel Jones settling in as the starter, the Colts are looking to take the next step in Steichen's fourth season. Indianapolis opened 2026 with a blowout loss to Baltimore.
Kansas City Chiefs: After a season derailed by Mahomes's knee injury, the Chiefs are betting on a healthy return and the addition of Kenneth Walker III to get back into playoff contention. Kansas City opened 2026 with a win over Denver.
Conclusion
Kalshi traders see Kansas City as the clear favorite in Sunday night's game, with Indianapolis's Week 1 blowout loss factoring into that price. Kalshi's prices for Colts-Chiefs will keep moving until the game ends.
What are the score predictions for Colts vs. Chiefs? As of this writing, Kalshi traders predict a point total of 46.
What is the spread for Colts vs. Chiefs? As of this writing, Kalshi traders have the Chiefs favored by 6 points.
Who is favored to win, Colts or Chiefs? As of this writing, Kalshi traders have the Chiefs favored at 72% to beat the Colts.
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