The Arizona Cardinals (1-1) visit the San Francisco 49ers (2-0) on Sunday, Sept. 27 at 4:05 p.m. ET at Levi's Stadium. Kalshi traders have the 49ers at 78% to win.
For informational purposes only. Not financial advice. See full disclaimer below. Kalshi is not affiliated with the NFL.
When and where do the Cardinals play the 49ers in Week 3 of the 2026 season?
The Cardinals and 49ers kick off Sunday, Sept. 27 at 4:05 p.m. ET at Levi's Stadium in Santa Clara, California, on FOX.
Who is favored to win the Cardinals vs. 49ers Week 3 game?
San Francisco went 12-5 in 2025 and lost 41-6 at Seattle in the Divisional round. Kyle Shanahan's team has opened 2026 with a 27-7 win over the Rams in Melbourne and a 35-13 win over Miami, with Raheem Morris now running the defense. Brock Purdy has completed 45 of 56 passes for 492 yards, five touchdowns, and one interception, and he has not been sacked. The injuries are piling up, though. Edge rusher Nick Bosa pulled his calf in Thursday's practice and is out, along with edge rusher Romello Height (hand), receiver Demarcus Robinson, and defensive tackle James Thompson Jr. Receiver Mike Evans (hip) is questionable, and the receiver room was already without Ricky Pearsall (season-ending knee surgery) and rookie De'Zhaun Stribling (ankle surgery), as of this writing.
Arizona went 3-14 in 2025 and fired Jonathan Gannon, hiring Mike LaFleur as head coach with Nathaniel Hackett as offensive coordinator. The Cardinals also released Kyler Murray in March, and Jacoby Brissett is the starter. They opened with a 26-14 upset win over the Chargers in Los Angeles, then managed 151 total yards in a 31-7 home loss to Seattle. Tight end Trey McBride caught eight passes and a touchdown in that game. Safety Dadrion Taylor is out, and defensive lineman Roy Lopez and cornerback Max Melton are questionable, as of this writing.
Kalshi power rankings
The 49ers enter as the No. 2 team in the league with a Power Score of 86.0, and Kalshi traders have them at 78% to qualify for the playoffs. The Cardinals rank 27th with a Power Score of 18.8, and Kalshi traders have them at 6% to reach the postseason. That is a 25-spot gap heading into Sunday, after San Francisco climbed two spots this week and Arizona fell two.
What the Kalshi market says
Kalshi traders have the 49ers at 78% to win and the Cardinals at 22%, as of this writing. That makes San Francisco a clear home favorite in the NFC West matchup.
What is the point spread for Cardinals vs. 49ers in Week 3?
Kalshi traders have the 49ers winning by more than 8.5 points at 48%, as of this writing.
What is the projected point total?
Kalshi traders have over 47.5 total points at 53%, as of this writing.
What is the biggest storyline in the Cardinals vs. 49ers Week 3 game?
It is how long Purdy can keep this up with a shrinking group of receivers, and how San Francisco's defense holds up without Bosa. Five different players have caught Purdy's touchdown passes, and the 49ers have not allowed a sack in two games. Arizona's defense has to find a way to get pressure, because its offense struggled to move the ball against Seattle and cannot count on winning a shootout. For the Cardinals, the path runs through McBride and a ball-control game that keeps Purdy on the sideline.
What are the Cardinals' and 49ers' expectations entering the 2026 season?
Arizona Cardinals: Arizona is starting over under LaFleur after the worst record in the NFC in 2025. The Week 1 win over the Chargers was a good start, but the roster is still being rebuilt.
San Francisco 49ers: The 49ers returned to the playoffs in 2025 and are aiming to win the NFC West back from Seattle. Staying healthy has been the biggest challenge for this group in recent years, and it already is again.
Conclusion
Kalshi traders have San Francisco at 78% at home against a Cardinals team that was held to 151 yards last week. The swing factor is whether the 49ers' injuries at receiver finally slow down Purdy's efficient start. Kalshi's prices for Cardinals vs. 49ers will keep moving until the game ends.
What are the score predictions for Cardinals vs. 49ers? Kalshi traders have over 47.5 total points at 53%, as of this writing.
What is the spread for Cardinals vs. 49ers? Kalshi traders have the 49ers winning by more than 8.5 points at 48%, as of this writing.
Who is favored to win, the Cardinals or the 49ers? Kalshi traders have the 49ers at 78% to win, as of this writing.
Follow Kalshi on X: @Kalshi | Image source: Alexander Jonesi
The opinions and perspectives presented in this article belong solely to the author. This is not financial advice and does not constitute an offer, solicitation, or recommendation to trade any specific product. Information is provided for convenience only on an "AS IS" basis. Past performance is not necessarily indicative of future results. 18+ only. Restrictions and eligibility requirements apply. Trading event contracts and trading leveraged products, including perpetual futures, involves significant risk and is not appropriate for everyone. Please carefully consider if it is appropriate for you in light of your personal financial circumstances. Kalshi products are not available in all jurisdictions. See kalshi.com/regulatory for more information. Kalshi is subject to U.S. regulatory oversight by the CFTC. Kalshi is not affiliated with the National Football League.
