The Miami Dolphins and San Francisco 49ers meet Sunday, September 20 at 4:25 p.m. ET at Levi's Stadium in Santa Clara, California. Miami enters 0-1, San Francisco enters 1-0. Kalshi traders have the 49ers at 90% to win and the Dolphins at 11%.
For informational purposes only. Not financial advice. See full disclaimer below. Kalshi is not affiliated with the NFL.
Who is favored to win the Dolphins-49ers Week 2 game?
Miami finished 7-10 in 2025, missing the playoffs for a second straight year, and fired head coach Mike McDaniel, hiring former Packers defensive coordinator Jeff Hafley. The Dolphins also released longtime starting quarterback Tua Tagovailoa this offseason, taking an NFL-record $99 million dead-cap hit, and signed Malik Willis, a free agent from Green Bay, as the new starter. Willis is playing through a toe injury and opened 2026 with a 27-13 loss to the Raiders. Rookie safety Kyle Louis suffered an MCL sprain in his Week 1 debut and has been placed on injured reserve, out at least four games, and linebacker Ronnie Harrison (hamstring) missed Wednesday's practice.
San Francisco went 12-5 in 2025, beat the Eagles in the Wild Card round and lost 41-6 to the Seahawks in the divisional round. Quarterback Brock Purdy and head coach Kyle Shanahan both return, and the 49ers opened 2026 with a win over the Rams. Running back Christian McCaffrey is on injured reserve with an Achilles/calf injury, and tight end Jake Tonges was placed on IR this week and is out for the season with a torn MCL. Tight end George Kittle, back from last season's Achilles tear, played in Week 1 and is expected to suit up again Sunday.
Kalshi power rankings
The 49ers enter as the No. 4 team in the league with a Power Score of 87.8 and a 69% playoff qualification price, while the Dolphins rank 31st with a Power Score of 7.4 and a 4% playoff price, a 27-spot gap heading into Sunday's game.
What the Kalshi market says
Kalshi traders have the 49ers at 90% and the Dolphins at 11% as San Francisco opens as a heavy favorite at home.
What is the point spread for Dolphins vs. 49ers in Week 2?
Kalshi traders predict the 49ers to be favored by 13.5 points over the Dolphins, as of this writing.
What is the projected point total?
Kalshi traders predict a point total of 44.5 for Sunday's game, as of this writing.
What is the biggest storyline in the Dolphins-49ers Week 2 game?
The sharpest storyline is Jeff Hafley's first road test as an NFL head coach against a 49ers team that's missing its top offensive weapon in Christian McCaffrey but still enters as a heavy favorite behind Brock Purdy and a healthy George Kittle.
What are the Dolphins' and 49ers' expectations entering the 2026 season?
Miami Dolphins: After a 7-10 season, a coaching change and the release of longtime starter Tua Tagovailoa, the Dolphins are in a reset year under Jeff Hafley with free-agent signee Malik Willis now at quarterback. Miami opened 2026 with a loss to the Raiders.
San Francisco 49ers: After reaching the divisional round, the 49ers are looking to build on a healthy Brock Purdy and a retooled receiver room that added Mike Evans. San Francisco opened 2026 with a win over the Rams.
Conclusion
Kalshi traders see San Francisco as the heavy favorite in Sunday's game, with Miami's coaching transition factoring into that price. Kalshi's prices for Dolphins-49ers will keep moving until the game ends.
What are the score predictions for Dolphins vs. 49ers? As of this writing, Kalshi traders predict a point total of 44.5.
What is the spread for Dolphins vs. 49ers? As of this writing, Kalshi traders have the 49ers favored by 13.5 points.
Who is favored to win, Dolphins or 49ers? As of this writing, Kalshi traders have the 49ers favored at 90% to beat the Dolphins.
Follow Kalshi on X: @Kalshi | Image source: Alexander Jonesi
The opinions and perspectives presented in this article belong solely to the author. This is not financial advice and does not constitute an offer, solicitation, or recommendation to trade any specific product. Information is provided for convenience only on an "AS IS" basis. Past performance is not necessarily indicative of future results. 18+ only. Restrictions and eligibility requirements apply. Trading event contracts and trading leveraged products, including perpetual futures, involves significant risk and is not appropriate for everyone. Please carefully consider if it is appropriate for you in light of your personal financial circumstances. Kalshi products are not available in all jurisdictions. See kalshi.com/regulatory for more information. Kalshi is subject to U.S. regulatory oversight by the CFTC. Kalshi is not affiliated with the National Football League.
