The Seattle Seahawks and Arizona Cardinals meet Sunday, September 20 at 4:05 p.m. ET at State Farm Stadium in Glendale, Arizona. Both teams enter 1-0. Kalshi traders have the Seahawks at 66% to win and the Cardinals at 35%.
For informational purposes only. Not financial advice. See full disclaimer below. Kalshi is not affiliated with the NFL.
Who is favored to win the Seahawks-Cardinals Week 2 game?
Seattle went 14-3 in 2025, won the NFC West and capped the year by beating the Patriots 29-13 in Super Bowl LX under head coach Mike Macdonald. Quarterback Sam Darnold has been ruled out for Sunday with a hip injury suffered in Week 1, and backup Drew Lock will start in his place; Lock threw for 187 yards and a touchdown in relief against New England. Wide receiver Cooper Kupp (back) and safety Nick Emmanwori (ankle/hip) were both limited in practice.
Arizona finished 3-14 in 2025 and fired head coach Jonathan Gannon, hiring Rams offensive coordinator Mike LaFleur. Quarterback Kyler Murray was released in free agency and signed with Minnesota, and veteran Jacoby Brissett is the new starter after throwing for 3,366 yards with 23 touchdowns filling in for an injured Murray in 2025. The Cardinals opened 2026 with a 26-14 win over the Chargers and enter Sunday looking to end a nine-game losing streak against Seattle.
Kalshi power rankings
The Seahawks enter as the No. 5 team in the league with a Power Score of 80.2 and a 67% playoff qualification price, while the Cardinals rank 25th with a Power Score of 34.4 and a 9% playoff price, a 20-spot gap heading into Sunday's game.
What the Kalshi market says
Kalshi traders have the Seahawks at 66% and the Cardinals at 35% as Seattle opens as a clear favorite on the road.
What is the point spread for Seahawks vs. Cardinals in Week 2?
Kalshi traders predict the Seahawks to be favored by 3.5 points over the Cardinals, as of this writing.
What is the projected point total?
Kalshi traders predict a point total of 41.5 for Sunday's game, as of this writing.
What is the biggest storyline in the Seahawks-Cardinals Week 2 game?
The sharpest storyline is Seattle's title defense opening with a backup quarterback. Drew Lock gets his first start since a five-start stint with the Giants in 2024, against a Cardinals team under a brand-new coaching staff still finding its footing.
What are the Seahawks' and Cardinals' expectations entering the 2026 season?
Seattle Seahawks: After winning it all, the Seahawks are looking to defend their title behind a defense that led the league in point differential last season. Seattle opened 2026 with a win over New England despite Sam Darnold's injury.
Arizona Cardinals: After a 3-14 season and a coaching change, the Cardinals are rebuilding around Mike LaFleur and Jacoby Brissett. Arizona opened 2026 with a win over the Chargers as it looks to snap a long losing streak against Seattle.
Conclusion
Kalshi traders see Seattle as the clear favorite in Sunday's game, with Arizona's rebuild and the Seahawks' quarterback change both factoring into that price. Kalshi's prices for Seahawks-Cardinals will keep moving until the game ends.
What are the score predictions for Seahawks vs. Cardinals? As of this writing, Kalshi traders predict a point total of 41.5.
What is the spread for Seahawks vs. Cardinals? As of this writing, Kalshi traders have the Seahawks favored by 3.5 points.
Who is favored to win, Seahawks or Cardinals? As of this writing, Kalshi traders have the Seahawks favored at 66% to beat the Cardinals.
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