Titans vs. 49ers odds: Tennessee heavily favored as Robert Saleh faces former team

The Tennessee Titans (0-0) open the 2026 preseason on the road against the San Francisco 49ers (0-0) Thursday, with kickoff set for 9:00 p.m. ET at Levi's Stadium. Kalshi has Tennessee as a 68% favorite to beat San Francisco, as of this writing, in new Titans coach Robert Saleh's first game against the franchise where he spent multiple seasons as defensive coordinator.

^{For informational purposes only. Not financial advice. See full disclaimer below. Kalshi is not affiliated with the NFL.}

Last year, San Francisco finished 12-5, won a Wild Card upset over the defending-champion Eagles, and lost to the Seahawks 41-6 in the Divisional round.

Tennessee finished 3-14, tied for the league's worst record. Saleh takes over the Titans this year after serving as San Francisco's defensive coordinator in 2025.

Kalshi gives Tennessee a 53% probability of winning by more than 5.5 points, as of this writing.

Kalshi has a 51% probability the two teams combine for more than 39.5 points, as of this writing.

The clearest angle heading into kickoff is how much of each starting lineup plays. Saleh has said the Titans will play "everyone," including starters on both sides of the ball, for more than a token series. Quarterback Cam Ward, who set a franchise rookie passing record with 3,169 yards a year ago, is expected to see the field, though only briefly before the offense turns to backups Mitchell Trubisky, Will Levis and Hendon Hooker. San Francisco's Brock Purdy is projected for a similarly short look before Mac Jones takes over.

The two teams held a joint practice Tuesday in Santa Clara, where Ward went 16-of-23 with two touchdowns against the 49ers' defense. San Francisco also made a round of roster moves this week, signing cornerback Eli Apple, defensive lineman Xavier Thomas and running back Zamir White to one-year deals.

Beyond the quarterbacks, this game is an early audition for backfield roles on both sides. Tennessee's Tony Pollard is the presumptive starter, but Tyjae Spears and Nick Singleton are expected to get extended carries to define the depth chart behind him. San Francisco's pass rush rotation behind Nick Bosa will be Mykel Williams, Bryce Huff, Robert Beal. William Bradley-King will also see extended run.

Kalshi has the Titans at 10% to win the AFC South Division, as of this writing.

Kalshi has the 49ers at 22% to win the NFC West Division, as of this writing.

Kalshi markets now predict:

When is Titans vs. 49ers? Thursday, August 13, 2026, with kickoff at 9:00 p.m. ET.
Where is the game? Levi's Stadium in Santa Clara, California.
How can I watch? Nationally on NFL Network; regionally on the Titans Preseason TV Network, flagship WKRN-News 2 Nashville.
What is Kalshi's current number? Tennessee is a 68% favorite over San Francisco, as of this writing.

Tennessee enters as a heavy favorite in Robert Saleh's first game against the franchise he left to become the Titans' head coach.

Follow Kalshi on X: @Kalshi | Image source: Tennessee Titans

^{This article contains content generated with the assistance of artificial intelligence. The opinions and perspectives presented in this article belong solely to the author. This is not financial advice. Trading on Kalshi involves risk and may not be appropriate for all. Members risk losing their cost to enter any transaction, including fees. You should carefully consider whether trading on Kalshi is appropriate for you in light of your investment experience and financial resources. Any trading decisions you make are solely your responsibility and at your own risk. Information is provided for convenience only on an "AS IS" basis. Past performance is not necessarily indicative of future results. Kalshi is subject to U.S. regulatory oversight by the CFTC. Kalshi is not affiliated with the National Football League.}